About Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT) is a protein
from Homo sapiens identified by UniProt accession
Q15274, 297 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Nicotinate-nucleotide pyrophosphorylase [carboxylating] |
|---|
| UniProt accession | Q15274 |
|---|
| Gene | QPRT |
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| Organism | Homo sapiens |
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| Length | 297 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- platelet crit · score 0.30
- platelet count · score 0.30
- protein measurement · score 0.28
- eosinophil count · score 0.16
- breast cancer · score 0.09
- esophageal adenocarcinoma · score 0.03
- Transcobalamin deficiency · score 0.03
- chronic kidney disease · score 0.03
- Barth syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15274-F1 | alphafold | PREDICTED | 96.89 | — |
Amino-acid sequence (297 residues)
MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFTLKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH
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