RNA-binding protein with serine-rich domain 1 (RNPS1)

About RNA-binding protein with serine-rich domain 1

RNA-binding protein with serine-rich domain 1 (RNPS1) is a protein from Homo sapiens identified by UniProt accession Q15287, 305 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	RNA-binding protein with serine-rich domain 1
UniProt accession	Q15287
Gene	RNPS1
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.07
birth weight · score 0.04
neoplasm · score 0.04
systolic blood pressure · score 0.04
cancer · score 0.03
acute myeloid leukemia · score 0.02
hepatocellular carcinoma · score 0.01
melanoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15287-F1	alphafold	PREDICTED	61.94	—

Amino-acid sequence (305 residues)

MDLSGVKKKS LLGVKENNKK SSTRAPSPTK RKDRSDEKSK DRSKDKGATK ESSEKDRGRD KTRKRRSASS GSSSTRSRSS STSSSGSSTS TGSSSGSSSS SASSRSGSSS TSRSSSSSSS SGSPSPSRRR HDNRRRSRSK SKPPKRDEKE RKRRSPSPKP TKVHIGRLTR NVTKDHIMEI FSTYGKIKMI DMPVERMHPH LSKGYAYVEF ENPDEAEKAL KHMDGGQIDG QEITATAVLA PWPRPPPRRF SPPRRMLPPP PMWRRSPPRM RRRSRSPRRR SPVRRRSRSP GRRRHRSRSS SNSSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards