About Retinoblastoma-binding protein 5
Retinoblastoma-binding protein 5 (RBBP5) is a protein
from Homo sapiens identified by UniProt accession
Q15291, 538 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Retinoblastoma-binding protein 5 |
|---|
| UniProt accession | Q15291 |
|---|
| Gene | RBBP5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 538 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- breast adenocarcinoma · score 0.26
- mean platelet volume · score 0.24
- basophil count · score 0.22
- pancreatic adenocarcinoma · score 0.18
- erythrocyte count · score 0.18
- aspartate aminotransferase measurement · score 0.18
- mean corpuscular hemoglobin concentration · score 0.17
- mean corpuscular hemoglobin · score 0.17
- head and neck squamous cell carcinoma · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15291-F1 | alphafold | PREDICTED | 77.72 | — |
Amino-acid sequence (538 residues)
MNLELLESFG QNYPEEADGT LDCISMALTC TFNRWGTLLA VGCNDGRIVI WDFLTRGIAK IISAHIHPVC SLCWSRDGHK LVSASTDNIV SQWDVLSGDC DQRFRFPSPI LKVQYHPRDQ NKVLVCPMKS APVMLTLSDS KHVVLPVDDD SDLNVVASFD RRGEYIYTGN AKGKILVLKT DSQDLVASFR VTTGTSNTTA IKSIEFARKG SCFLINTADR IIRVYDGREI LTCGRDGEPE PMQKLQDLVN RTPWKKCCFS GDGEYIVAGS ARQHALYIWE KSIGNLVKIL HGTRGELLLD VAWHPVRPII ASISSGVVSI WAQNQVENWS AFAPDFKELD ENVEYEERES EFDIEDEDKS EPEQTGADAA EDEEVDVTSV DPIAAFCSSD EELEDSKALL YLPIAPEVED PEENPYGPPP DAVQTSLMDE GASSEKKRQS SADGSQPPKK KPKTTNIELQ GVPNDEVHPL LGVKGDGKSK KKQAGRPKGS KGKEKDSPFK PKLYKGDRGL PLEGSAKGKV QAELSQPLTA GGAISELL
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