Interferon regulatory factor 4 (IRF4)

About Interferon regulatory factor 4

Interferon regulatory factor 4 (IRF4) is a protein from Homo sapiens identified by UniProt accession Q15306, 451 residues long. MolForge cross-references it against 0 known binders and 764 disease associations.

Target properties

Protein name	Interferon regulatory factor 4
UniProt accession	Q15306
Gene	IRF4
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (764)

Diseases linked to this target (Open Targets).

multiple myeloma · score 0.56
neurodegenerative disease · score 0.54
chronic lymphocytic leukemia · score 0.53
hair color · score 0.45
diffuse large B-cell lymphoma · score 0.43
lymphocyte count · score 0.42
skin pigmentation · score 0.41
hair colour measurement · score 0.40
adult T-cell leukemia/lymphoma · score 0.39
eosinophil count · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15306-F1	alphafold	PREDICTED	71.58	—

Amino-acid sequence (451 residues)

MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF RIPWKHAGKQ DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD PYKVYRIVPE GAKKGAKQLT LEDPQMSMSH PYTMTTPYPS LPAQQVHNYM MPPLDRSWRD YVPDQPHPEI PYQCPMTFGP RGHHWQGPAC ENGCQVTGTF YACAPPESQA PGVPTEPSIR SAEALAFSDC RLHICLYYRE ILVKELTTSS PEGCRISHGH TYDASNLDQV LFPYPEDNGQ RKNIEKLLSH LERGVVLWMA PDGLYAKRLC QSRIYWDGPL ALCNDRPNKL ERDQTCKLFD TQQFLSELQA FAHHGRSLPR FQVTLCFGEE FPDPQRQRKL ITAHVEPLLA RQLYYFAQQN SGHFLRGYDL PEHISNPEDY HRSIRHSSIQ E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards