About POU domain, class 4, transcription factor 3
POU domain, class 4, transcription factor 3 (POU4F3) is a protein
from Homo sapiens identified by UniProt accession
Q15319, 338 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | POU domain, class 4, transcription factor 3 |
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| UniProt accession | Q15319 |
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| Gene | POU4F3 |
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| Organism | Homo sapiens |
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| Length | 338 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (112)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.68
- deafness · score 0.67
- neurodegenerative disease · score 0.53
- nonsyndromic genetic hearing loss · score 0.37
- Hearing impairment · score 0.31
- Rare genetic deafness · score 0.27
- hearing loss, autosomal recessive · score 0.27
- genetic disorder · score 0.19
- Congenital sensorineural hearing impairment · score 0.11
- Red cell distribution width · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15319-F1 | alphafold | PREDICTED | 64.74 | — |
Amino-acid sequence (338 residues)
MMAMNSKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSSTVPISHP AALTSHPHHA VHQGLEGDLL EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHTVAPH SAMPACLSDV ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH
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