Keratin, type I cuticular Ha1 (KRT31)

About Keratin, type I cuticular Ha1

Keratin, type I cuticular Ha1 (KRT31) is a protein from Homo sapiens identified by UniProt accession Q15323, 416 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha1
UniProt accession	Q15323
Gene	KRT31
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
hair color · score 0.22
head and neck squamous cell carcinoma · score 0.19
ovarian cancer · score 0.18
glioblastoma multiforme · score 0.18
prostate adenocarcinoma · score 0.18
clear cell renal carcinoma · score 0.18
breast adenocarcinoma · score 0.18
neuroblastoma · score 0.13
low grade glioma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15323-F1	alphafold	PREDICTED	78.40	—

Amino-acid sequence (416 residues)

MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT PCAPRPRCGP CNSFVR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards