Ankyrin repeat domain-containing protein 1 (ANKRD1)

About Ankyrin repeat domain-containing protein 1

Ankyrin repeat domain-containing protein 1 (ANKRD1) is a protein from Homo sapiens identified by UniProt accession Q15327, 319 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 1
UniProt accession	Q15327
Gene	ANKRD1
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

familial isolated dilated cardiomyopathy · score 0.37
electrocardiography · score 0.26
refractive error measurement · score 0.26
autosomal dominant dilated cardiomyopathy · score 0.23
left atrial volume measurement · score 0.23
ankrd1-related dilated cardiomyopathy · score 0.19
Abnormality of the cardiovascular system · score 0.19
Abnormality of refraction · score 0.19
dilated cardiomyopathy · score 0.19
cardiomyopathy · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15327-F1	alphafold	PREDICTED	82.78	—

Amino-acid sequence (319 residues)

MMVLKVEELV TGKKNGNGEA GEFLPEDFRD GEYEAAVTLE KQEDLKTLLA HPVTLGEQQW KSEKQREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVVKEP EPEIITEPVD VPTFLKAALE NKLPVVEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWASRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LIMYGADLNI KNCAGKTPMD LVLHWQNGTK AIFDSLRENS YKTSRIATF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards