About Leucine-rich repeat-containing protein 41
Leucine-rich repeat-containing protein 41 (LRRC41) is a protein
from Homo sapiens identified by UniProt accession
Q15345, 812 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 41 |
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| UniProt accession | Q15345 |
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| Gene | LRRC41 |
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| Organism | Homo sapiens |
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| Length | 812 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.44
- non-Hodgkins lymphoma · score 0.37
- genetic disorder · score 0.36
- breast ductal adenocarcinoma · score 0.33
- hereditary breast carcinoma · score 0.32
- clear cell renal carcinoma · score 0.18
- pancreatic adenocarcinoma · score 0.18
- hereditary breast ovarian cancer syndrome · score 0.17
- Hereditary breast and ovarian cancer syndrome · score 0.17
- hepatocellular carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15345-F1 | alphafold | PREDICTED | 70.96 | — |
Amino-acid sequence (812 residues)
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE APGTKRSPSA PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA RTRQGPGAES EDLYDFVFIV AGEKEDGEEM EIGEVACGAL DGSDPSCLGL PALEASQRFR SISTLELFTV PLSTEAALTL CHLLSSWVSL ESLTLSYNGL GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT RAIVRALPLL RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS FHDMNLADCQ SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG NSTLKGLRLP GNRLGNAGLL ALADVFSEDS SSSLCQLDIS SNCIKPDGLL EFAKRLERWG RGAFGHLRLF QNWLDQDAVT AREAIRRLRA TCHVVSDSWD SSQAFADYVS TM
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