About Ribosomal protein S6 kinase alpha-2
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) is a protein
from Homo sapiens identified by UniProt accession
Q15349, 733 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | Ribosomal protein S6 kinase alpha-2 |
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| UniProt accession | Q15349 |
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| Gene | RPS6KA2 |
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| Organism | Homo sapiens |
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| Length | 733 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (97)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.38
- autism spectrum disorder · score 0.33
- macrovascular complications of diabetes · score 0.28
- breast adenocarcinoma · score 0.26
- viral load · score 0.25
- bipolar disorder · score 0.23
- glioblastoma multiforme · score 0.22
- bipolar I disorder · score 0.19
- ovarian cancer · score 0.18
- lung adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15349-F1 | alphafold | PREDICTED | 77.17 | — |
Amino-acid sequence (733 residues)
MDLSMKKFAV RRFFSVYLRR KSRSKSSSLS RLEEEGVVKE IDISHHVKEG FEKADPSQFE LLKVLGQGSY GKVFLVRKVK GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHSLGI IYRDLKPENI LLDEEGHIKI TDFGLSKEAI DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSGEAQSLL RALFKRNPCN RLGAGIDGVE EIKRHPFFVT IDWNTLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS PGVPPSANAH HLFRGFSFVA SSLIQEPSQQ DLHKVPVHPI VQQLHGNNIH FTDGYEIKED IGVGSYSVCK RCVHKATDTE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK FVYLVMELMR GGELLDRILR QRYFSEREAS DVLCTITKTM DYLHSQGVVH RDLKPSNILY RDESGSPESI RVCDFGFAKQ LRAGNGLLMT PCYTANFVAP EVLKRQGYDA ACDIWSLGIL LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPHQR LTAMQVLKHP WVVNREYLSP NQLSRQDVHL VKGAMAATYF ALNRTPQAPR LEPVLSSNLA QRRGMKRLTS TRL
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