Poly(rC)-binding protein 1 (PCBP1)

About Poly(rC)-binding protein 1

Poly(rC)-binding protein 1 (PCBP1) is a protein from Homo sapiens identified by UniProt accession Q15365, 356 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	Poly(rC)-binding protein 1
UniProt accession	Q15365
Gene	PCBP1
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (181)

Diseases linked to this target (Open Targets).

colorectal adenocarcinoma · score 0.54
Burkitts lymphoma · score 0.46
neurodegenerative disease · score 0.45
lean body mass · score 0.44
fat body mass · score 0.36
mean corpuscular volume · score 0.34
neutrophil count · score 0.31
erythrocyte count · score 0.30
IGF-1 measurement · score 0.29
leukocyte count · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15365-F1	alphafold	PREDICTED	68.96	—

Amino-acid sequence (356 residues)

MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE KGMGCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards