Poly(rC)-binding protein 2 (PCBP2)

About Poly(rC)-binding protein 2

Poly(rC)-binding protein 2 (PCBP2) is a protein from Homo sapiens identified by UniProt accession Q15366, 365 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Poly(rC)-binding protein 2
UniProt accession	Q15366
Gene	PCBP2
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

severe acute respiratory syndrome · score 0.46
neurodegenerative disease · score 0.28
Parkinson disease · score 0.28
multiple sclerosis · score 0.28
lysosomal storage disease · score 0.28
Alzheimer disease · score 0.28
lean body mass · score 0.15
self reported educational attainment · score 0.15
late-onset Alzheimers disease · score 0.14
sex hormone-binding globulin measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15366-F1	alphafold	PREDICTED	67.20	—

Amino-acid sequence (365 residues)

MDTGVIEGGL NVTLTIRLLM HGKEVGSIIG KKGESVKKMR EESGARINIS EGNCPERIIT LAGPTNAIFK AFAMIIDKLE EDISSSMTNS TAASRPPVTL RLVVPASQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG IPQSIIECVK QICVVMLETL SQSPPKGVTI PYRPKPSSSP VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ PDLTKLHQLA MQQSHFPMTH GNTGFSGIES SSPEVKGYWG LDASAQTTSH ELTIPNDLIG CIIGRQGAKI NEIRQMSGAQ IKIANPVEGS TDRQVTITGS AASISLAQYL INVRLSSETG GMGSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards