About GTP-binding protein Rheb
GTP-binding protein Rheb (RHEB) is a protein
from Homo sapiens identified by UniProt accession
Q15382, 184 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | GTP-binding protein Rheb |
|---|
| UniProt accession | Q15382 |
|---|
| Gene | RHEB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- papillary renal cell carcinoma · score 0.37
- isolated focal cortical dysplasia type II · score 0.34
- uterine neoplasm · score 0.32
- bladder transitional cell carcinoma · score 0.32
- breast adenocarcinoma · score 0.29
- neurodegenerative disease · score 0.28
- lung adenocarcinoma · score 0.27
- hemimegalencephaly · score 0.27
- endometrial cancer · score 0.23
- squamous cell lung carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15382-F1 | alphafold | PREDICTED | 92.51 | — |
Amino-acid sequence (184 residues)
MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKM DGAASQGKSS CSVM
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