Angiopoietin-1 (ANGPT1)

About Angiopoietin-1

Angiopoietin-1 (ANGPT1) is a protein from Homo sapiens identified by UniProt accession Q15389, 498 residues long. MolForge cross-references it against 0 known binders and 534 disease associations.

Target properties

Protein name	Angiopoietin-1
UniProt accession	Q15389
Gene	ANGPT1
Organism	Homo sapiens
Length	498 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (534)

Diseases linked to this target (Open Targets).

intraocular pressure measurement · score 0.50
mean corpuscular volume · score 0.48
erythrocyte count · score 0.46
reticulocyte count · score 0.45
glaucoma · score 0.43
mean corpuscular hemoglobin concentration · score 0.43
reticulocyte measurement · score 0.42
mean corpuscular hemoglobin · score 0.42
aortic measurement · score 0.41
open-angle glaucoma · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15389-F1	alphafold	PREDICTED	83.10	—

Amino-acid sequence (498 residues)

MTVFLSFAFL AAILTHIGCS NQRRSPENSG RRYNRIQHGQ CAYTFILPEH DGNCRESTTD QYNTNALQRD APHVEPDFSS QKLQHLEHVM ENYTQWLQKL ENYIVENMKS EMAQIQQNAV QNHTATMLEI GTSLLSQTAE QTRKLTDVET QVLNQTSRLE IQLLENSLST YKLEKQLLQQ TNEILKIHEK NSLLEHKILE MEGKHKEELD TLKEEKENLQ GLVTRQTYII QELEKQLNRA TTNNSVLQKQ QLELMDTVHN LVNLCTKEGV LLKGGKREEE KPFRDCADVY QAGFNKSGIY TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN YRLYLKGHTG TAGKQSSLIL HGADFSTKDA DNDNCMCKCA LMLTGGWWFD ACGPSNLNGM FYTAGQNHGK LNGIKWHYFK GPSYSLRSTT MMIRPLDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards