Mitochondrial fission regulator 1 (MTFR1)

About Mitochondrial fission regulator 1

Mitochondrial fission regulator 1 (MTFR1) is a protein from Homo sapiens identified by UniProt accession Q15390, 333 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Mitochondrial fission regulator 1
UniProt accession	Q15390
Gene	MTFR1
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

lysosomal storage disease · score 0.37
Parkinson disease · score 0.37
Alzheimer disease · score 0.37
multiple sclerosis · score 0.37
neurodegenerative disease · score 0.37
protein measurement · score 0.31
smoking status measurement · score 0.28
antisocial behaviour measurement · score 0.26
attention deficit hyperactivity disorder · score 0.26
substance abuse · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15390-F1	alphafold	PREDICTED	65.68	—

Amino-acid sequence (333 residues)

MLGWIKRLIR MVFQQVGVSM QSVLWSRKPY GSSRSIVRKI GTNLSLIQCP RVQFQINSHA TEWSPSHPGE DAVASFADVG WVAKEEGECS ARLRTEVRSR PPLQDDLLFF EKAPSRQISL PDLSQEEPQL KTPALANEEA LQKICALENE LAALRAQIAK IVTQQEQQNL TAGDLDSTTF GTIPPHPPPP PPPLPPPALG LHQSTSAVDL IKERREKRAN AGKTLVKNNP KKPEMPNMLE ILKEMNSVKL RSVKRSEQDV KPKPVDATDP AALIAEALKK KFAYRYRSDS QDEVEKGIPK SESEATSERV LFGPHMLKPT GKMKALIENV SDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards