About Delta(24)-sterol reductase
Delta(24)-sterol reductase (DHCR24) is a protein
from Homo sapiens identified by UniProt accession
Q15392, 516 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Delta(24)-sterol reductase |
|---|
| UniProt accession | Q15392 |
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| Gene | DHCR24 |
|---|
| Organism | Homo sapiens |
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| Length | 516 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (147)
Diseases linked to this target (Open Targets).
- desmosterolosis · score 0.81
- Non-immune hydrops fetalis · score 0.43
- genetic disorder · score 0.19
- schizophrenia · score 0.11
- hepatocellular carcinoma · score 0.09
- urinary bladder carcinoma · score 0.08
- visceral adipose tissue measurement · score 0.07
- phospholipid measurement · score 0.07
- white matter microstructure measurement · score 0.07
- melanoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15392-F1 | alphafold | PREDICTED | 92.45 | — |
Amino-acid sequence (516 residues)
MEPAVSLAVC ALLFLLWVRL KGLEFVLIHQ RWVFVCLFLL PLSLIFDIYY YVRAWVVFKL SSAPRLHEQR VRDIQKQVRE WKEQGSKTFM CTGRPGWLTV SLRVGKYKKT HKNIMINLMD ILEVDTKKQI VRVEPLVTMG QVTALLTSIG WTLPVLPELD DLTVGGLIMG TGIESSSHKY GLFQHICTAY ELVLADGSFV RCTPSENSDL FYAVPWSCGT LGFLVAAEIR IIPAKKYVKL RFEPVRGLEA ICAKFTHESQ RQENHFVEGL LYSLDEAVIM TGVMTDEAEP SKLNSIGNYY KPWFFKHVEN YLKTNREGLE YIPLRHYYHR HTRSIFWELQ DIIPFGNNPI FRYLFGWMVP PKISLLKLTQ GETLRKLYEQ HHVVQDMLVP MKCLQQALHT FQNDIHVYPI WLCPFILPSQ PGLVHPKGNE AELYIDIGAY GEPRVKHFEA RSCMRQLEKF VRSVHGFQML YADCYMNREE FWEMFDGSLY HKLREKLGCQ DAFPEVYDKI CKAARH
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