Nuclear receptor subfamily 6 group A member 1 (NR6A1)

About Nuclear receptor subfamily 6 group A member 1

Nuclear receptor subfamily 6 group A member 1 (NR6A1) is a protein from Homo sapiens identified by UniProt accession Q15406, 480 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Nuclear receptor subfamily 6 group A member 1
UniProt accession	Q15406
Gene	NR6A1
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

age at menarche · score 0.26
alcohol consumption measurement · score 0.17
cutaneous melanoma · score 0.15
brain aneurysm · score 0.12
genetic disorder · score 0.12
lung adenocarcinoma · score 0.10
hepatocellular carcinoma · score 0.09
body height · score 0.05
neoplasm · score 0.05
vital capacity · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15406-F1	alphafold	PREDICTED	76.97	—

Amino-acid sequence (480 residues)

MERDEPPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTISV SDDRAEQRTC LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSSR SVELNGFMAF REQYMGMSVP PHYQYIPHLF SYSGHSPLLP QQARSLDPQS YSLIHQLLSA EDLEPLGTPM LIEDGYAVTQ AELFALLCRL ADELLFRQIA WIKKLPFFCE LSIKDYTCLL SSTWQELILL SSLTVYSKQI FGELADVTAK YSPSDEELHR FSDEGMEVIE RLIYLYHKFH QLKVSNEEYA CMKAINFLNQ DIRGLTSASQ LEQLNKRYWY ICQDFTEYKY THQPNRFPDL MMCLPEIRYI AGKMVNVPLE QLPLLFKVVL HSCKTSVGKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards