About Ribosomal protein S6 kinase alpha-1
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) is a protein
from Homo sapiens identified by UniProt accession
Q15418, 735 residues long.
MolForge cross-references it against 0 known binders and
214 disease associations.
Target properties
| Protein name | Ribosomal protein S6 kinase alpha-1 |
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| UniProt accession | Q15418 |
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| Gene | RPS6KA1 |
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| Organism | Homo sapiens |
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| Length | 735 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (214)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- lymphocyte count · score 0.35
- mean corpuscular hemoglobin concentration · score 0.34
- mean corpuscular volume · score 0.33
- mean corpuscular hemoglobin · score 0.32
- thyroid gland adenocarcinoma · score 0.29
- hemoglobin A1 measurement · score 0.27
- breast adenocarcinoma · score 0.26
- type 2 diabetes mellitus · score 0.25
- glioblastoma multiforme · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15418-F1 | alphafold | PREDICTED | 76.69 | — |
Amino-acid sequence (735 residues)
MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS ILAQRRVRKL PSTTL
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