About Splicing factor 3B subunit 4
Splicing factor 3B subunit 4 (SF3B4) is a protein
from Homo sapiens identified by UniProt accession
Q15427, 424 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Splicing factor 3B subunit 4 |
|---|
| UniProt accession | Q15427 |
|---|
| Gene | SF3B4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 424 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- Nager acrofacial dysostosis · score 0.73
- Nager syndrome · score 0.70
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.45
- SF3B4-related acrofacial dysostosis · score 0.37
- Acrofacial dysostosis, Rodríguez type · score 0.37
- Micrognathia · score 0.34
- Stenosis of the external auditory canal · score 0.34
- Malar flattening · score 0.34
- Midface retrusion · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15427-F1 | alphafold | PREDICTED | 73.21 | — |
Amino-acid sequence (424 residues)
MAAGPISERN QDATVYVGGL DEKVSEPLLW ELFLQAGPVV NTHMPKDRVT GQHQGYGFVE FLSEEDADYA IKIMNMIKLY GKPIRVNKAS AHNKNLDVGA NIFIGNLDPE IDEKLLYDTF SAFGVILQTP KIMRDPDTGN SKGYAFINFA SFDASDAAIE AMNGQYLCNR PITVSYAFKK DSKGERHGSA AERLLAAQNP LSQADRPHQL FADAPPPPSA PNPVVSSLGS GLPPPGMPPP GSFPPPVPPP GALPPGIPPA MPPPPMPPGA AGHGPPSAGT PGAGHPGHGH SHPHPFPPGG MPHPGMSQMQ LAHHGPHGLG HPHAGPPGSG GQPPPRPPPG MPHPGPPPMG MPPRGPPFGS PMGHPGPMPP HGMRGPPPLM PPHGYTGPPR PPPYGYQRGP LPPPRPTPRP PVPPRGPLRG PLPQ
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