Splicing factor 3A subunit 2 (SF3A2)

About Splicing factor 3A subunit 2

Splicing factor 3A subunit 2 (SF3A2) is a protein from Homo sapiens identified by UniProt accession Q15428, 464 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Splicing factor 3A subunit 2
UniProt accession	Q15428
Gene	SF3A2
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

body mass index · score 0.19
neurodegenerative disease · score 0.17
mean corpuscular volume · score 0.15
body height · score 0.12
pulse pressure measurement · score 0.09
migraine disorder · score 0.08
triple-negative breast cancer · score 0.07
systolic blood pressure · score 0.07
body fat percentage · score 0.04
eosinophil count · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15428-F1	alphafold	PREDICTED	64.05	—

Amino-acid sequence (464 residues)

MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG LPPRPPLPES LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV HPPAPGVHPP APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM HPQAPGVHPQ PPGVHPSAPG VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP SEGPGNIPPP PPTN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards