SH2 domain-containing adapter protein B (SHB)

About SH2 domain-containing adapter protein B

SH2 domain-containing adapter protein B (SHB) is a protein from Homo sapiens identified by UniProt accession Q15464, 509 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	SH2 domain-containing adapter protein B
UniProt accession	Q15464
Gene	SHB
Organism	Homo sapiens
Length	509 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

balding measurement · score 0.35
platelet count · score 0.32
FEV/FVC ratio · score 0.32
brain measurement · score 0.28
hair colour measurement · score 0.28
acne · score 0.28
pulse pressure measurement · score 0.28
lymphocyte count · score 0.28
monocyte count · score 0.27
hair shape measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15464-F1	alphafold	PREDICTED	58.74	—

Amino-acid sequence (509 residues)

MAKWLNKYFS LGNSKTKSPP QPPRPDYREQ RRRGERPSQP PQAVPQASSA ASASCGPATA SCFSASSGSL PDDSGSTSDL IRAYRAQKER DFEDPYNGPG SSLRKLRAMC RLDYCGGSGE PGGVQRAFSA SSASGAAGCC CASSGAGAAA SSSSSSGSPH LYRSSSERRP ATPAEVRYIS PKHRLIKVES AAGGGAGDPL GGACAGGRTW SPTACGGKKL LNKCAASAAE ESGAGKKDKV TIADDYSDPF DAKNDLKSKA GKGESAGYME PYEAQRIMTE FQRQESVRSQ HKGIQLYDTP YEPEGQSVDS DSESTVSPRL RESKLPQDDD RPADEYDQPW EWNRVTIPAL AAQFNGNEKR QSSPSPSRDR RRQLRAPGGG FKPIKHGSPE FCGILGERVD PAVPLEKQIW YHGAISRGDA ENLLRLCKEC SYLVRNSQTS KHDYSLSLRS NQGFMHMKLA KTKEKYVLGQ NSPPFDSVPE VIHYYTTRKL PIKGAEHLSL LYPVAVRTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards