About Sonic hedgehog protein
Sonic hedgehog protein (SHH) is a protein
from Homo sapiens identified by UniProt accession
Q15465, 462 residues long.
MolForge cross-references it against 0 known binders and
1,062 disease associations.
Target properties
| Protein name | Sonic hedgehog protein |
|---|
| UniProt accession | Q15465 |
|---|
| Gene | SHH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 462 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1062)
Diseases linked to this target (Open Targets).
- holoprosencephaly 3 · score 0.84
- microphthalmia, isolated, with coloboma 5 · score 0.73
- solitary median maxillary central incisor syndrome · score 0.72
- holoprosencephaly · score 0.66
- schizencephaly · score 0.65
- triphalangeal thumb-polysyndactyly syndrome · score 0.60
- Solitary median maxillary central incisor · score 0.55
- Absent tibia - polydactyly · score 0.47
- polydactyly of a triphalangeal thumb · score 0.46
- creatinine measurement · score 0.44
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15465-F1 | alphafold | PREDICTED | 78.38 | — |
Amino-acid sequence (462 residues)
MLLLARCLLL VLVSSLLVCS GLACGPGRGF GKRRHPKKLT PLAYKQFIPN VAEKTLGASG RYEGKISRNS ERFKELTPNY NPDIIFKDEE NTGADRLMTQ RCKDKLNALA ISVMNQWPGV KLRVTEGWDE DGHHSEESLH YEGRAVDITT SDRDRSKYGM LARLAVEAGF DWVYYESKAH IHCSVKAENS VAAKSGGCFP GSATVHLEQG GTKLVKDLSP GDRVLAADDQ GRLLYSDFLT FLDRDDGAKK VFYVIETREP RERLLLTAAH LLFVAPHNDS ATGEPEASSG SGPPSGGALG PRALFASRVR PGQRVYVVAE RDGDRRLLPA AVHSVTLSEE AAGAYAPLTA QGTILINRVL ASCYAVIEEH SWAHRAFAPF RLAHALLAAL APARTDRGGD SGGGDRGGGG GRVALTAPGA ADAPGAGATA GIHWYSQLLY QIGTWLLDSE ALHPLGMAVK SS
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