Nuclear receptor subfamily 0 group B member 2 (NR0B2)

About Nuclear receptor subfamily 0 group B member 2

Nuclear receptor subfamily 0 group B member 2 (NR0B2) is a protein from Homo sapiens identified by UniProt accession Q15466, 257 residues long. MolForge cross-references it against 0 known binders and 336 disease associations.

Target properties

Protein name	Nuclear receptor subfamily 0 group B member 2
UniProt accession	Q15466
Gene	NR0B2
Organism	Homo sapiens
Length	257 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (336)

Diseases linked to this target (Open Targets).

obesity · score 0.53
inherited obesity · score 0.45
diastolic blood pressure · score 0.16
serum gamma-glutamyl transferase measurement · score 0.11
neoplasm · score 0.09
alkaline phosphatase measurement · score 0.09
hepatocellular carcinoma · score 0.09
IGF-1 measurement · score 0.09
eosinophil count · score 0.08
Barrett's esophagus · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15466-F1	alphafold	PREDICTED	81.60	—

Amino-acid sequence (257 residues)

MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC APHRTCREAL DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL AQDAVTFEVA EAPVPSILKK ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ CCLESFWSLE LSPKEYACLK GTILFNPDVP GLQAASHIGH LQQEAHWVLC EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI IGDVDIAGLL GDMLLLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards