Homeobox protein SIX1 (SIX1)

About Homeobox protein SIX1

Homeobox protein SIX1 (SIX1) is a protein from Homo sapiens identified by UniProt accession Q15475, 284 residues long. MolForge cross-references it against 0 known binders and 523 disease associations.

Target properties

Protein name	Homeobox protein SIX1
UniProt accession	Q15475
Gene	SIX1
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (523)

Diseases linked to this target (Open Targets).

Branchio-otic syndrome · score 0.81
autosomal dominant nonsyndromic hearing loss · score 0.67
branchio-oto-renal syndrome · score 0.49
BOR syndrome · score 0.46
hearing loss · score 0.42
branchiootic syndrome · score 0.38
colorectal adenocarcinoma · score 0.37
bile duct carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15475-F1	alphafold	PREDICTED	75.59	—

Amino-acid sequence (284 residues)

MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQGNMGH ARSSNYSLPG LTASQPSHGL QTHQHQLQDS LLGPLTSSLV DLGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards