About Mediator of RNA polymerase II transcription subunit 22
Mediator of RNA polymerase II transcription subunit 22 (MED22) is a protein
from Homo sapiens identified by UniProt accession
Q15528, 200 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 22 |
|---|
| UniProt accession | Q15528 |
|---|
| Gene | MED22 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 200 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- alkaline phosphatase measurement · score 0.12
- breast adenocarcinoma · score 0.11
- neutrophil count · score 0.05
- cholelithiasis · score 0.05
- hepatocellular carcinoma · score 0.04
- pancreas disease · score 0.04
- gallbladder disease · score 0.04
- biliary tract disease · score 0.04
- neutrophil percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15528-F1 | alphafold | PREDICTED | 78.10 | — |
Amino-acid sequence (200 residues)
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ RNQQLRTLQE ECDRKLITLR DEISIDLYEL EEEYYSSSSS LCEANDLPLC EAYGRLDLDT DSADGLSAPL LASPEPSAGP LQVAAPAHSH AGGPGPTEHA
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