Transcription initiation factor TFIID subunit 7 (TAF7)

About Transcription initiation factor TFIID subunit 7

Transcription initiation factor TFIID subunit 7 (TAF7) is a protein from Homo sapiens identified by UniProt accession Q15545, 349 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Transcription initiation factor TFIID subunit 7
UniProt accession	Q15545
Gene	TAF7
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
breast adenocarcinoma · score 0.25
glioblastoma multiforme · score 0.25
neurodegenerative disease · score 0.24
head and neck squamous cell carcinoma · score 0.18
esophageal cancer · score 0.15
small cell lung carcinoma · score 0.14
mean platelet volume · score 0.12
nonpapillary renal cell carcinoma · score 0.07
glioblastoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15545-F1	alphafold	PREDICTED	76.07	—

Amino-acid sequence (349 residues)

MSKSKDDAPH ELESQFILRL PPEYASTVRR AVQSGHVNLK DRLTIELHPD GRHGIVRVDR VPLASKLVDL PCVMESLKTI DKKTFYKTAD ICQMLVSTVD GDLYPPVEEP VASTDPKASK KKDKDKEKKF IWNHGITLPL KNVRKRRFRK TAKKKYIESP DVEKEVKRLL STDAEAVSTR WEIIAEDETK EAENQGLDIS SPGMSGHRQG HDSLEHDELR EIFNDLSSSS EDEDETQHQD EEDINIIDTE EDLERQLQDK LNESDEQHQE NEGTNQLVMG IQKQIDNMKG KLQETQDRAK RQEDLIMKVE NLALKNRFQA VLDELKQKED REKEQLSSLQ EELESLLEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards