Monocyte to macrophage differentiation factor (MMD)

About Monocyte to macrophage differentiation factor

Monocyte to macrophage differentiation factor (MMD) is a protein from Homo sapiens identified by UniProt accession Q15546, 238 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Monocyte to macrophage differentiation factor
UniProt accession	Q15546
Gene	MMD
Organism	Homo sapiens
Length	238 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.38
phosphatidate measurement · score 0.30
Jaundice · score 0.28
age at menarche · score 0.05
Familial exudative vitreoretinopathy · score 0.04
immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.04
Kimura disease · score 0.04
hyper-IgM syndrome type 3 · score 0.04
autoimmune lymphoproliferative syndrome · score 0.04
glycoprotein storage disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15546-F1	alphafold	PREDICTED	92.27	—

Amino-acid sequence (238 residues)

MRFKNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFMRHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards