Telomeric repeat-binding factor 2 (TERF2)

About Telomeric repeat-binding factor 2

Telomeric repeat-binding factor 2 (TERF2) is a protein from Homo sapiens identified by UniProt accession Q15554, 542 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Telomeric repeat-binding factor 2
UniProt accession	Q15554
Gene	TERF2
Organism	Homo sapiens
Length	542 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
breast adenocarcinoma · score 0.27
head and neck squamous cell carcinoma · score 0.26
endometrial cancer · score 0.24
esophageal cancer · score 0.21
gastric adenocarcinoma · score 0.21
Parkinson disease · score 0.19
lysosomal storage disease · score 0.19
Alzheimer disease · score 0.19
multiple sclerosis · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15554-F1	alphafold	PREDICTED	67.99	—

Amino-acid sequence (542 residues)

MAAGAGTAGP ASGPGVVRDP AASQPRKRPG REGGEGARRS DTMAGGGGSS DGSGRAAGRR ASRSSGRARR GRHEPGLGGP AERGAGEARL EEAVNRWVLK FYFHEALRAF RGSRYGDFRQ IRDIMQALLV RPLGKEHTVS RLLRVMQCLS RIEEGENLDC SFDMEAELTP LESAINVLEM IKTEFTLTEA VVESSRKLVK EAAVIICIKN KEFEKASKIL KKHMSKDPTT QKLRNDLLNI IREKNLAHPV IQNFSYETFQ QKMLRFLESH LDDAEPYLLT MAKKALKSES AASSTGKEDK QPAPGPVEKP PREPARQLRN PPTTIGMMTL KAAFKTLSGA QDSEAAFAKL DQKDLVLPTQ ALPASPALKN KRPRKDENES SAPADGEGGS ELQPKNKRMT ISRLVLEEDS QSTEPSAGLN SSQEAASAPP SKPTVLNQPL PGEKNPKVPK GKWNSSNGVE EKETWVEEDE LFQVQAAPDE DSTTNITKKQ KWTVEESEWV KAGVQKYGEG NWAAISKNYP FVNRTAVMIK DRWRTMKRLG MN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards