About Dual specificity testis-specific protein kinase 1
Dual specificity testis-specific protein kinase 1 (TESK1) is a protein
from Homo sapiens identified by UniProt accession
Q15569, 626 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Dual specificity testis-specific protein kinase 1 |
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| UniProt accession | Q15569 |
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| Gene | TESK1 |
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| Organism | Homo sapiens |
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| Length | 626 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (20)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.23
- endometrial cancer · score 0.18
- glioblastoma multiforme · score 0.16
- head and neck squamous cell carcinoma · score 0.10
- mean platelet volume · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- protein measurement · score 0.05
- pentosuria · score 0.05
- glomerular disease · score 0.01
- Alzheimer disease · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15569-F1 | alphafold | PREDICTED | 61.74 | — |
Amino-acid sequence (626 residues)
MAGERPPLRG PGPGPGEVPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA EKIGAGFFSE VYKVRHRQSG QVMVLKMNKL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV HQGQLHALTE YMNGGTLEQL LSSPEPLSWP VRLHLALDIA RGLRYLHSKG VFHRDLTSKN CLVRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCNLEPST RAPFTEITQH LEWILEQLPE PAPLTRTALT HNQGSVARGG PSATLPRPDP RLSRSRSDLF LPPSPESPPN WGDNLTRVNP FSLREDLRGG KIKLLDTPSK PVLPLVPPSP FPSTQLPLVT TPETLVQPGT PARRCRSLPS SPELPRRMET ALPGPGPPAV GPSAEEKMEC EGSSPEPEPP GPAPQLPLAV ATDNFISTCS SASQPWSPRS GPVLNNNPPA VVVNSPQGWA GEPWNRAQHS LPRAAALERT EPSPPPSAPR EPDEGLPCPG CCLGPFSFGF LSMCPRPTPA VARYRNLNCE AGSLLCHRGH HAKPPTPSLQ LPGARS
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