About TATA box-binding protein-associated factor RNA polymerase I subunit A
TATA box-binding protein-associated factor RNA polymerase I subunit A (TAF1A) is a protein
from Homo sapiens identified by UniProt accession
Q15573, 450 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | TATA box-binding protein-associated factor RNA polymerase I subunit A |
|---|
| UniProt accession | Q15573 |
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| Gene | TAF1A |
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| Organism | Homo sapiens |
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| Length | 450 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- familial isolated dilated cardiomyopathy · score 0.37
- Agents acting on the renin-angiotensin system use measurement · score 0.27
- angina pectoris · score 0.18
- Keloid · score 0.15
- cardiomyopathy, familial restrictive, 6 · score 0.14
- dilated cardiomyopathy · score 0.12
- reactive cutaneous fibrous lesion · score 0.11
- hypertrophy · score 0.04
- coronary artery disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15573-F1 | alphafold | PREDICTED | 85.76 | — |
Amino-acid sequence (450 residues)
MSDFSEELKG PVTDDEEVET SVLSGAGMHF PWLQTYVETV AIGGKRRKDF AQTTSACLSF IQEALLKHQW QQAAEYMYSY FQTLEDSDSY KRQAAPEIIW KLGSEILFYH PKSNMESFNT FANRMKNIGV MNYLKISLQH ALYLLHHGML KDAKRNLSEA ETWRHGENTS SREILINLIQ AYKGLLQYYT WSEKKMELSK LDKDDYAYNA VAQDVFNHSW KTSANISALI KIPGVWDPFV KSYVEMLEFY GDRDGAQEVL TNYAYDEKFP SNPNAHIYLY NFLKRQKAPR SKLISVLKIL YQIVPSHKLM LEFHTLLRKS EKEEHRKLGL EVLFGVLDFA GCTKNITAWK YLAKYLKNIL MGNHLAWVQE EWNSRKNWWP GFHFSYFWAK SDWKEDTALA CEKAFVAGLL LGKGCRYFRY ILKQDHQILG KKIKRMKRSV KKYSIVNPRL
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