Homeobox protein TGIF1 (TGIF1)

About Homeobox protein TGIF1

Homeobox protein TGIF1 (TGIF1) is a protein from Homo sapiens identified by UniProt accession Q15583, 401 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	Homeobox protein TGIF1
UniProt accession	Q15583
Gene	TGIF1
Organism	Homo sapiens
Length	401 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

holoprosencephaly · score 0.74
neurodegenerative disease · score 0.53
neutrophil count · score 0.42
colorectal adenocarcinoma · score 0.41
mean corpuscular volume · score 0.39
alkaline phosphatase measurement · score 0.37
midline interhemispheric variant of holoprosencephaly · score 0.37
septopreoptic holoprosencephaly · score 0.37
semilobar holoprosencephaly · score 0.37
microform holoprosencephaly · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15583-F1	alphafold	PREDICTED	58.10	—

Amino-acid sequence (401 residues)

MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP RLSRGTLAYL PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT KAGPRRPHRW ELPRSPSQGA QGPAPRRRLL ETMKGIVAAS GSETEDEDSM DIPLDLSSSA GSGKRRRRGN LPKESVQILR DWLYEHRYNA YPSEQEKALL SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS RRGAKISETS SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK SGPSTNTQSG LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards