Na(+)/H(+) exchange regulatory cofactor NHE-RF2…

About Na(+)/H(+) exchange regulatory cofactor NHE-RF2

Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) is a protein from Homo sapiens identified by UniProt accession Q15599, 337 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Na(+)/H(+) exchange regulatory cofactor NHE-RF2
UniProt accession	Q15599
Gene	NHERF2
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.39
erythrocyte count · score 0.36
diastolic blood pressure · score 0.35
systolic blood pressure · score 0.34
reticulocyte count · score 0.32
hematocrit · score 0.31
platelet count · score 0.30
red blood cell density measurement · score 0.29
mean corpuscular hemoglobin concentration · score 0.28
pulse pressure measurement · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15599-F1	alphafold	PREDICTED	68.83	—

Amino-acid sequence (337 residues)

MAAPEPLRPR LCRLVRGEQG YGFHLHGEKG RRGQFIRRVE PGSPAEAAAL RAGDRLVEVN GVNVEGETHH QVVQRIKAVE GQTRLLVVDQ ETDEELRRRQ LTCTEEMAQR GLPPAHDPWE PKPDWAHTGS HSSEAGKKDV SGPLRELRPR LCHLRKGPQG YGFNLHSDKS RPGQYIRSVD PGSPAARSGL RAQDRLIEVN GQNVEGLRHA EVVASIKARE DEARLLVVDP ETDEHFKRLR VTPTEEHVEG PLPSPVTNGT SPAQLNGGSA CSSRSDLPGS DKDTEDGSAW KQDPFQESGL HLSPTAAEAK EKARAMRVNK RAPQMDWNRK REIFSNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)