About Tumor necrosis factor receptor type 1-associated DEATH domain protein
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a protein
from Homo sapiens identified by UniProt accession
Q15628, 312 residues long.
MolForge cross-references it against 0 known binders and
208 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
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| UniProt accession | Q15628 |
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| Gene | TRADD |
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| Organism | Homo sapiens |
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| Length | 312 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (208)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.37
- breast adenocarcinoma · score 0.24
- early-onset zonular cataract · score 0.17
- cataract 5 multiple types · score 0.17
- isolated agammaglobulinemia · score 0.06
- non-small cell lung carcinoma · score 0.06
- common variable immunodeficiency · score 0.06
- hair shape measurement · score 0.06
- hyper-IgM syndrome type 2 · score 0.06
- Immunodeficiency due to a late component of complements deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15628-F1 | alphafold | PREDICTED | 83.25 | — |
Amino-acid sequence (312 residues)
MAAGQNGHEE WVGSAYLFVE SSLDKVVLSD AYAHPQQKVA VYRALQAALA ESGGSPDVLQ MLKIHRSDPQ LIVQLRFCGR QPCGRFLRAY REGALRAALQ RSLAAALAQH SVPLQLELRA GAERLDALLA DEERCLSCIL AQQPDRLRDE ELAELEDALR NLKCGSGARG GDGEVASAPL QPPVPSLSEV KPPPPPPPAQ TFLFQGQPVV NRPLSLKDQQ TFARSVGLKW RKVGRSLQRG CRALRDPALD SLAYEYEREG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLTDPNGG LA
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