RISC-loading complex subunit TARBP2 (TARBP2)

About RISC-loading complex subunit TARBP2

RISC-loading complex subunit TARBP2 (TARBP2) is a protein from Homo sapiens identified by UniProt accession Q15633, 366 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	RISC-loading complex subunit TARBP2
UniProt accession	Q15633
Gene	TARBP2
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (124)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
hepatocellular carcinoma · score 0.10
neoplasm · score 0.09
adrenal cortex carcinoma · score 0.09
azoospermia · score 0.08
viral disease · score 0.08
body mass index · score 0.07
diffuse large B-cell lymphoma · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.06
partial chromosome Y deletion · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15633-F1	alphafold	PREDICTED	74.68	—

Amino-acid sequence (366 residues)

MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL LKAEGQAHQP NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM LEPALEDSSS FSPLDSSLPE DIPVFTAAAA ATPVPSVVLT RSPPMELQPP VSPQQSECNP VGALQELVVQ KGWRLPEYTV TQESGPAHRK EFTMTCRVER FIEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEVEP DDDHFSIGVG SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGSLGAL GPACCRVLSE LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS ATTREAARGE AARRALQYLK IMAGSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards