About Splicing factor 1
Splicing factor 1 (SF1) is a protein
from Homo sapiens identified by UniProt accession
Q15637, 639 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Splicing factor 1 |
|---|
| UniProt accession | Q15637 |
|---|
| Gene | SF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 639 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- Neurodevelopmental disorder · score 0.27
- urate measurement · score 0.14
- lymphocyte count · score 0.09
- Hereditary breast and ovarian cancer syndrome · score 0.08
- body height · score 0.06
- breast-ovarian cancer, familial, susceptibility to, 1 · score 0.06
- ovarian cancer · score 0.06
- familial pancreatic carcinoma · score 0.06
- Lynch syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15637-F1 | alphafold | PREDICTED | 64.19 | — |
Amino-acid sequence (639 residues)
MATGANATPL DFPSKKRKRS RWNQDTMEQK TVIPGMPTVI PPGLTREQER AYIVQLQIED LTRKLRTGDL GIPPNPEDRS PSPEPIYNSE GKRLNTREFR TRKKLEEERH NLITEMVALN PDFKPPADYK PPATRVSDKV MIPQDEYPEI NFVGLLIGPR GNTLKNIEKE CNAKIMIRGK GSVKEGKVGR KDGQMLPGED EPLHALVTAN TMENVKKAVE QIRNILKQGI ETPEDQNDLR KMQLRELARL NGTLREDDNR ILRPWQSSET RSITNTTVCT KCGGAGHIAS DCKFQRPGDP QSAQDKARMD KEYLSLMAEL GEAPVPASVG STSGPATTPL ASAPRPAAPA NNPPPPSLMS TTQSRPPWMN SGPSESRPYH GMHGGGPGGP GGGPHSFPHP LPSLTGGHGG HPMQHNPNGP PPPWMQPPPP PMNQGPHPPG HHGPPPMDQY LGSTPVGSGV YRLHQGKGMM PPPPMGMMPP PPPPPSGQPP PPPSGPLPPW QQQQQQPPPP PPPSSSMASS TPLPWQQNTT TTTTSAGTGS IPPWQQQQAA AAASPGAPQM QGNPTMVPLP PGVQPPLPPG APPPPPPPPP GSAGMMYAPP PPPPPPMDPS NFVTMMGMGV AGMPPFGMPP APPPPPPQN
Explore Splicing factor 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets