About Cdc42-interacting protein 4
Cdc42-interacting protein 4 (TRIP10) is a protein
from Homo sapiens identified by UniProt accession
Q15642, 601 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Cdc42-interacting protein 4 |
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| UniProt accession | Q15642 |
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| Gene | TRIP10 |
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| Organism | Homo sapiens |
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| Length | 601 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (152)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.29
- glioblastoma multiforme · score 0.18
- neoplasm · score 0.10
- triple-negative breast cancer · score 0.08
- non-small cell lung carcinoma · score 0.07
- isolated agammaglobulinemia · score 0.05
- Chronic mucocutaneous candidosis · score 0.05
- severe combined immunodeficiency due to CARD11 deficiency · score 0.05
- hyper-IgM syndrome type 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15642-F1 | alphafold | PREDICTED | 79.76 | — |
Amino-acid sequence (601 residues)
MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV KKYLPKRPAK DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL ELTKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL GTPSDGRPEL RGPGRSRTKR WPFGKKNKPR PPPLSPLGGP VPSALPNGPP SPRSGRDPLA ILSEISKSVK PRLASFRSLR GSRGTVVTED FSHLPPEQQR KRLQQQLEER SRELQKEVDQ REALKKMKDV YEKTPQMGDP ASLEPQIAET LSNIERLKLE VQKYEAWLAE AESRVLSNRG DSLSRHARPP DPPASAPPDS SSNSASQDTK ESSEEPPSEE SQDTPIYTEF DEDFEEEPTS PIGHCVAIYH FEGSSEGTIS MAEGEDLSLM EEDKGDGWTR VRRKEGGEGY VPTSYLRVTL N
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