Pachytene checkpoint protein 2 homolog (TRIP13)

About Pachytene checkpoint protein 2 homolog

Pachytene checkpoint protein 2 homolog (TRIP13) is a protein from Homo sapiens identified by UniProt accession Q15645, 432 residues long. MolForge cross-references it against 0 known binders and 259 disease associations.

Target properties

Protein name	Pachytene checkpoint protein 2 homolog
UniProt accession	Q15645
Gene	TRIP13
Organism	Homo sapiens
Length	432 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (259)

Diseases linked to this target (Open Targets).

oocyte maturation defect 9 · score 0.68
mosaic variegated aneuploidy syndrome · score 0.65
neurodegenerative disease · score 0.55
Nephroblastoma · score 0.37
lysosomal storage disease · score 0.37
Red cell distribution width · score 0.12
hepatocellular carcinoma · score 0.12
neoplasm · score 0.11
glioblastoma multiforme · score 0.10
non-small cell lung carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15645-F1	alphafold	PREDICTED	86.70	—

Amino-acid sequence (432 residues)

MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN IVFGDYTWTE FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF QLNEDGPSSE NLEEETENII AANHWVLPAA EFHGLWDSLV YDVEVKSHLL DYVMTTLLFS DKNVNSNLIT WNRVVLLHGP PGTGKTSLCK ALAQKLTIRL SSRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQDLI DDKDALVFVL IDEVESLTAA RNACRAGTEP SDAIRVVNAV LTQIDQIKRH SNVVILTTSN ITEKIDVAFV DRADIKQYIG PPSAAAIFKI YLSCLEELMK CQIIYPRQQL LTLRELEMIG FIENNVSKLS LLLNDISRKS EGLSGRVLRK LPFLAHALYV QAPTVTIEGF LQALSLAVDK QFEERKKLAA YI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards