About 2'-5'-oligoadenylate synthase-like protein
2'-5'-oligoadenylate synthase-like protein (OASL) is a protein
from Homo sapiens identified by UniProt accession
Q15646, 514 residues long.
MolForge cross-references it against 0 known binders and
179 disease associations.
Target properties
| Protein name | 2'-5'-oligoadenylate synthase-like protein |
|---|
| UniProt accession | Q15646 |
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| Gene | OASL |
|---|
| Organism | Homo sapiens |
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| Length | 514 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (179)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.33
- alkaline phosphatase measurement · score 0.29
- type 2 diabetes mellitus · score 0.27
- mathematical ability · score 0.27
- C-reactive protein measurement · score 0.25
- serum metabolite measurement · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.21
- intelligence · score 0.18
- aspartate aminotransferase measurement · score 0.14
- endocrine system disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15646-F1 | alphafold | PREDICTED | 92.17 | — |
Amino-acid sequence (514 residues)
MALMQELYST PASRLDSFVA QWLQPHREWK EEVLDAVRTV EEFLRQEHFQ GKRGLDQDVR VLKVVKVGSF GNGTVLRSTR EVELVAFLSC FHSFQEAAKH HKDVLRLIWK TMWQSQDLLD LGLEDLRMEQ RVPDALVFTI QTRGTAEPIT VTIVPAYRAL GPSLPNSQPP PEVYVSLIKA CGGPGNFCPS FSELQRNFVK HRPTKLKSLL RLVKHWYQQY VKARSPRANL PPLYALELLT IYAWEMGTEE DENFMLDEGF TTVMDLLLEY EVICIYWTKY YTLHNAIIED CVRKQLKKER PIILDPADPT LNVAEGYRWD IVAQRASQCL KQDCCYDNRE NPISSWNVKR ARDIHLTVEQ RGYPDFNLIV NPYEPIRKVK EKIRRTRGYS GLQRLSFQVP GSERQLLSSR CSLAKYGIFS HTHIYLLETI PSEIQVFVKN PDGGSYAYAI NPNSFILGLK QQIEDQQGLP KKQQQLEFQG QVLQDWLGLG IYGIQDSDTL ILSKKKGEAL FPAS
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