About Activating signal cointegrator 1
Activating signal cointegrator 1 (TRIP4) is a protein
from Homo sapiens identified by UniProt accession
Q15650, 581 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Activating signal cointegrator 1 |
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| UniProt accession | Q15650 |
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| Gene | TRIP4 |
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| Organism | Homo sapiens |
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| Length | 581 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- spinal muscular atrophy with congenital bone fractures 1 · score 0.70
- congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome · score 0.66
- prenatal-onset spinal muscular atrophy with congenital bone fractures · score 0.61
- genetic disorder · score 0.19
- total blood protein measurement · score 0.11
- mean corpuscular volume · score 0.08
- neutrophil count · score 0.07
- mean platelet volume · score 0.06
- age at menarche · score 0.05
- myeloid white cell count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15650-F1 | alphafold | PREDICTED | 71.18 | — |
Amino-acid sequence (581 residues)
MAVAGAVSGE PLVHWCTQQL RKTFGLDVSE EIIQYVLSIE SAEEIREYVT DLLQGNEGKK GQFIEELITK WQKNDQELIS DPLQQCFKKD EILDGQKSGD HLKRGRKKGR NRQEVPAFTE PDTTAEVKTP FDLAKAQENS NSVKKKTKFV NLYTREGQDR LAVLLPGRHP CDCLGQKHKL INNCLICGRI VCEQEGSGPC LFCGTLVCTH EEQDILQRDS NKSQKLLKKL MSGVENSGKV DISTKDLLPH QELRIKSGLE KAIKHKDKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK LERETLQKRE EELRELRHAS RLSKKVTIDF AGRKILEEEN SLAEYHSRLD ETIQAIANGT LNQPLTKLDR SSEEPLGVLV NPNMYQSPPQ WVDHTGAASQ KKAFRSSGFG LEFNSFQHQL RIQDQEFQEG FDGGWCLSVH QPWASLLVRG IKRVEGRSWY TPHRGRLWIA ATAKKPSPQE VSELQATYRL LRGKDVEFPN DYPSGCLLGC VDLIDCLSQK QFKEQFPDIS QESDSPFVFI CKNPQEMVVK FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V
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