High mobility group nucleosome-binding…

About High mobility group nucleosome-binding domain-containing protein 3

High mobility group nucleosome-binding domain-containing protein 3 (HMGN3) is a protein from Homo sapiens identified by UniProt accession Q15651, 99 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	High mobility group nucleosome-binding domain-containing protein 3
UniProt accession	Q15651
Gene	HMGN3
Organism	Homo sapiens
Length	99 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

MODY · score 0.10
vitamin D measurement · score 0.08
type 2 diabetes mellitus · score 0.08
hyperinsulinism due to glucokinase deficiency · score 0.06
hyperproinsulinemia · score 0.06
hyperinsulinism due to INSR deficiency · score 0.06
type 1 diabetes mellitus · score 0.06
Huntington disease · score 0.06
diabetes mellitus, transient neonatal, 2 · score 0.06
transient neonatal diabetes mellitus · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15651-F1	alphafold	PREDICTED	65.22	—

Amino-acid sequence (99 residues)

MPKRKSPENT EGKDGSKVTK QEPTRRSARL SAKPAPPKPE PKPRKTSAKK EPGAKISRGA KGKKEEKQEA GKEGTAPSEN GETKAEEAQK TESVDNEGE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)