NF-kappa-B inhibitor beta (NFKBIB)

About NF-kappa-B inhibitor beta

NF-kappa-B inhibitor beta (NFKBIB) is a protein from Homo sapiens identified by UniProt accession Q15653, 356 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	NF-kappa-B inhibitor beta
UniProt accession	Q15653
Gene	NFKBIB
Organism	Homo sapiens
Length	356 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (121)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.14
body height · score 0.11
gastrointestinal stromal tumor · score 0.07
common variable immunodeficiency · score 0.05
isolated agammaglobulinemia · score 0.05
Sepsis · score 0.05
immunodeficiency 18 · score 0.04
combined immunodeficiency with skin granulomas · score 0.04
polyarticular juvenile idiopathic arthritis, rheumatoid factor positive · score 0.04
immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15653-F1	alphafold	PREDICTED	76.36	—

Amino-acid sequence (356 residues)

MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV FGYVTEDGDT ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL AAILGETSTV EKLYAAGAGL CVAERRGHTA LHLACRVGAH ACARALLQPR PRRPREAPDT YLAQGPDRTP DTNHTPVALY PDSDLEKEEE ESEEDWKLQL EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC GRSPLHLAVE AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP DDPRPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards