Thyroid receptor-interacting protein 6 (TRIP6)

About Thyroid receptor-interacting protein 6

Thyroid receptor-interacting protein 6 (TRIP6) is a protein from Homo sapiens identified by UniProt accession Q15654, 476 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Thyroid receptor-interacting protein 6
UniProt accession	Q15654
Gene	TRIP6
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.27
neurodegenerative disease · score 0.25
alkaline phosphatase measurement · score 0.25
resting heart rate · score 0.24
hair color · score 0.21
electrocardiography · score 0.18
skin pigmentation · score 0.18
heart rate response to recovery post exercise · score 0.17
hair colour measurement · score 0.16
heart rate · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15654-F1	alphafold	PREDICTED	62.98	—

Amino-acid sequence (476 residues)

MSGPTWLPPK QPEPARAPQG RAIPRGTPGP PPAHGAALQP HPRVNFCPLP SEQCYQAPGG PEDRGPAWVG SHGVLQHTQG LPADRGGLRP GSLDAEIDLL SSTLAELNGG RGHASRRPDR QAYEPPPPPA YRTGSLKPNP ASPLPASPYG GPTPASYTTA STPAGPAFPV QVKVAQPVRG CGPPRRGASQ ASGPLPGPHF PLPGRGEVWG PGYRSQREPG PGAKEEAAGV SGPAGRGRGG EHGPQVPLSQ PPEDELDRLT KKLVHDMNHP PSGEYFGQCG GCGEDVVGDG AGVVALDRVF HVGCFVCSTC RAQLRGQHFY AVERRAYCEG CYVATLEKCA TCSQPILDRI LRAMGKAYHP GCFTCVVCHR GLDGIPFTVD ATSQIHCIED FHRKFAPRCS VCGGAIMPEP GQEETVRIVA LDRSFHIGCY KCEECGLLLS SEGECQGCYP LDGHILCKAC SAWRIQELSA TVTTDC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards