Rho-related GTP-binding protein RhoH (RHOH)

About Rho-related GTP-binding protein RhoH

Rho-related GTP-binding protein RhoH (RHOH) is a protein from Homo sapiens identified by UniProt accession Q15669, 191 residues long. MolForge cross-references it against 0 known binders and 360 disease associations.

Target properties

Protein name	Rho-related GTP-binding protein RhoH
UniProt accession	Q15669
Gene	RHOH
Organism	Homo sapiens
Length	191 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (360)

Diseases linked to this target (Open Targets).

T-cell immunodeficiency with epidermodysplasia verruciformis · score 0.44
epidermodysplasia verruciformis · score 0.43
combined immunodeficiency · score 0.42
Combined immunodeficiency · score 0.42
breast ductal adenocarcinoma · score 0.37
lymphoid neoplasm · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
chronic lymphocytic leukemia · score 0.30
acute myeloid leukemia · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15669-F1	alphafold	PREDICTED	93.13	—

Amino-acid sequence (191 residues)

MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR RLFSINECKI F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards