About Twist-related protein 1
Twist-related protein 1 (TWIST1) is a protein
from Homo sapiens identified by UniProt accession
Q15672, 202 residues long.
MolForge cross-references it against 0 known binders and
844 disease associations.
Target properties
| Protein name | Twist-related protein 1 |
|---|
| UniProt accession | Q15672 |
|---|
| Gene | TWIST1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 202 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (844)
Diseases linked to this target (Open Targets).
- Saethre-Chotzen syndrome · score 0.84
- TWIST1-related craniosynostosis · score 0.75
- syndromic craniosynostosis · score 0.59
- isolated oxycephaly · score 0.55
- Craniosynostosis, Boston type · score 0.53
- neurodegenerative disease · score 0.50
- hair shape measurement · score 0.47
- vital capacity · score 0.45
- forced expiratory volume · score 0.44
- coronary artery disease · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15672-F1 | alphafold | PREDICTED | 66.31 | — |
Amino-acid sequence (202 residues)
MMQDVSSSPV SPADDSLSNS EEEPDRQQPP SGKRGGRKRR SSRRSAGGGA GPGGAAGGGV GGGDEPGSPA QGKRGKKSAG CGGGGGAGGG GGSSSGGGSP QSYEELQTQR VMANVRERQR TQSLNEAFAA LRKIIPTLPS DKLSKIQTLK LAARYIDFLY QVLQSDELDS KMASCSYVAH ERLSYAFSVW RMEGAWSMSA SH
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