About U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) is a protein
from Homo sapiens identified by UniProt accession
Q15696, 482 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
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| UniProt accession | Q15696 |
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| Gene | ZRSR2 |
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| Organism | Homo sapiens |
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| Length | 482 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- myelodysplastic syndrome · score 0.39
- blastic plasmacytoid dendritic cell neoplasm · score 0.38
- chronic myelomonocytic leukemia · score 0.37
- myelofibrosis · score 0.37
- colorectal adenocarcinoma · score 0.37
- acute myeloid leukemia · score 0.32
- lysosomal storage disease · score 0.30
- myeloproliferative disorder · score 0.28
- chronic myelogenous leukemia · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15696-F1 | alphafold | PREDICTED | 69.37 | — |
Amino-acid sequence (482 residues)
MAAPEKMTFP EKPSHKKYRA ALKKEKRKKR RQELARLRDS GLSQKEEEED TFIEEQQLEE EKLLERERQR LHEEWLLREQ KAQEEFRIKK EKEEAAKKRQ EEQERKLKEQ WEEQQRKERE EEEQKRQEKK EKEEALQKML DQAENELENG TTWQNPEPPV DFRVMEKDRA NCPFYSKTGA CRFGDRCSRK HNFPTSSPTL LIKSMFTTFG MEQCRRDDYD PDASLEYSEE ETYQQFLDFY EDVLPEFKNV GKVIQFKVSC NLEPHLRGNV YVQYQSEEEC QAALSLFNGR WYAGRQLQCE FCPVTRWKMA ICGLFEIQQC PRGKHCNFLH VFRNPNNEFW EANRDIYLSP DRTGSSFGKN SERRERMGHH DDYYSRLRGR RNPSPDHSYK RNGESERKSS RHRGKKSHKR TSKSRERHNS RSRGRNRDRS RDRSRGRGSR SRSRSRSRRS RRSRSQSSSR SRSRGRRRSG NRDRTVQSPK SK
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