ALX homeobox protein 1 (ALX1)

About ALX homeobox protein 1

ALX homeobox protein 1 (ALX1) is a protein from Homo sapiens identified by UniProt accession Q15699, 326 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	ALX homeobox protein 1
UniProt accession	Q15699
Gene	ALX1
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

frontonasal dysplasia - severe microphthalmia - severe facial clefting syndrome · score 0.77
Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome · score 0.64
frontonasal dysplasia · score 0.45
forced expiratory volume · score 0.41
vital capacity · score 0.40
peak expiratory flow · score 0.35
cortical thickness · score 0.34
facial morphology measurement · score 0.33
brain measurement · score 0.32
neuroimaging measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15699-F1	alphafold	PREDICTED	60.33	—

Amino-acid sequence (326 residues)

MEFLSEKFAL KSPPSKNSDF YMGAGGPLEH VMETLDNESF YSKASAGKCV QAFGPLPRAE HHVRLERTSP CQDSSVNYGI TKVEGQPLHT ELNRAMDNCN SLRMSPVKGM QEKGELDELG DKCDSNVSSS KKRRHRTTFT SLQLEELEKV FQKTHYPDVY VREQLALRTE LTEARVQVWF QNRRAKWRKR ERYGQIQQAK SHFAATYDIS VLPRTDSYPQ IQNNLWAGNA SGGSVVTSCM LPRDTSSCMT PYSHSPRTDS SYTGFSNHQN QFSHVPLNNF FTDSLLTGAT NGHAFETKPE FERRSSSIAV LRMKAKEHTA NISWAM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards