About ETS-related transcription factor Elf-2
ETS-related transcription factor Elf-2 (ELF2) is a protein
from Homo sapiens identified by UniProt accession
Q15723, 593 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | ETS-related transcription factor Elf-2 |
|---|
| UniProt accession | Q15723 |
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| Gene | ELF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 593 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.34
- creatinine measurement · score 0.30
- neurodegenerative disease · score 0.28
- cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome · score 0.27
- body height · score 0.23
- chronotype measurement · score 0.21
- forced expiratory volume · score 0.18
- reticulocyte measurement · score 0.16
- sitting height measurement · score 0.15
- body weight · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15723-F1 | alphafold | PREDICTED | 49.33 | — |
Amino-acid sequence (593 residues)
MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA AQVLVYDDET YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV FVPPCVSTPE FIHAAMRPDV ITETVVEVST EESEPMDTSP IPTSPDSHEP MKKKKVGRKP KTQQSPISNG SPELGIKKKP REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR AEKGVARVVN ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS LGQKISTVAV QSVNAGAPLI TSTSPTTATS PKVVIQTIPT VMPASTENGD KITMQPAKII TIPATQLAQC QLQTKSNLTG SGSINIVGTP LAVRALTPVS IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV AKKQEHDVKT LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK
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