Metastasis-suppressor KiSS-1 (KISS1)

About Metastasis-suppressor KiSS-1

Metastasis-suppressor KiSS-1 (KISS1) is a protein from Homo sapiens identified by UniProt accession Q15726, 138 residues long. MolForge cross-references it against 0 known binders and 506 disease associations.

Target properties

Protein name	Metastasis-suppressor KiSS-1
UniProt accession	Q15726
Gene	KISS1
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (506)

Diseases linked to this target (Open Targets).

hypogonadotropic hypogonadism · score 0.46
breast adenocarcinoma · score 0.25
testosterone measurement · score 0.23
age at menarche · score 0.20
low grade glioma · score 0.14
polycystic ovary syndrome · score 0.13
neoplasm · score 0.11
disorder of sexual differentiation · score 0.11
Genetic 46,XY disorder of sex development · score 0.11
Miscarriage · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15726-F1	alphafold	PREDICTED	59.40	—

Amino-acid sequence (138 residues)

MNSLVSWQLL LFLCATHFGE PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR FGKREAAPGN HGRSAGRG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards