About Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) is a protein
from Homo sapiens identified by UniProt accession
Q15738, 373 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
|---|
| UniProt accession | Q15738 |
|---|
| Gene | NSDHL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 373 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (237)
Diseases linked to this target (Open Targets).
- CHILD syndrome · score 0.82
- CK syndrome · score 0.78
- neurodegenerative disease · score 0.40
- genetic disorder · score 0.18
- connective tissue disease · score 0.15
- Intellectual disability · score 0.12
- unilateral polymicrogyria · score 0.12
- Abnormal cerebral white matter morphology · score 0.12
- Seizure · score 0.12
- Tall stature · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15738-F1 | alphafold | PREDICTED | 88.61 | — |
Amino-acid sequence (373 residues)
MEPAVSEPMR DQVARTHLTE DTPKVNADIE KVNQNQAKRC TVIGGSGFLG QHMVEQLLAR GYAVNVFDIQ QGFDNPQVRF FLGDLCSRQD LYPALKGVNT VFHCASPPPS SNNKELFYRV NYIGTKNVIE TCKEAGVQKL ILTSSASVIF EGVDIKNGTE DLPYAMKPID YYTETKILQE RAVLGANDPE KNFLTTAIRP HGIFGPRDPQ LVPILIEAAR NGKMKFVIGN GKNLVDFTFV ENVVHGHILA AEQLSRDSTL GGKAFHITND EPIPFWTFLS RILTGLNYEA PKYHIPYWVA YYLALLLSLL VMVISPVIQL QPTFTPMRVA LAGTFHYYSC ERAKKAMGYQ PLVTMDDAME RTVQSFRHLR RVK
Explore Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets