NGFI-A-binding protein 2 (NAB2)

About NGFI-A-binding protein 2

NGFI-A-binding protein 2 (NAB2) is a protein from Homo sapiens identified by UniProt accession Q15742, 525 residues long. MolForge cross-references it against 0 known binders and 175 disease associations.

Target properties

Protein name	NGFI-A-binding protein 2
UniProt accession	Q15742
Gene	NAB2
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (175)

Diseases linked to this target (Open Targets).

solitary fibrous tumor · score 0.38
hemangiopericytoma · score 0.37
meninges hemangiopericytoma · score 0.37
T-Cell Prolymphocytic Leukemia · score 0.37
meningioma · score 0.37
Transitional Meningioma · score 0.37
thyroid neoplasm · score 0.37
Dedifferentiated Solitary Fibrous Tumor · score 0.37
pleural solitary fibrous tumor · score 0.37
insomnia measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15742-F1	alphafold	PREDICTED	62.47	—

Amino-acid sequence (525 residues)

MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG DPRIWPGRST PESDVGAGGE EEAGSPPFSP PAGGGVPEGT GAGGLAAGGT GGGPDRLEPE MVRMVVESVE RIFRSFPRGD AGEVTSLLKL NKKLARSVGH IFEMDDNDSQ KEEEIRKYSI IYGRFDSKRR EGKQLSLHEL TINEAAAQFC MRDNTLLLRR VELFSLSRQV ARESTYLSSL KGSRLHPEEL GGPPLKKLKQ EVGEQSHPEI QQPPPGPESY VPPYRPSLEE DSASLSGESL DGHLQAVGSC PRLTPPPADL PLALPAHGLW SRHILQQTLM DEGLRLARLV SHDRVGRLSP CVPAKPPLAE FEEGLLDRCP APGPHPALVE GRRSSVKVEA EASRQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards