About Neutral amino acid transporter B(0)
Neutral amino acid transporter B(0) (SLC1A5) is a protein
from Homo sapiens identified by UniProt accession
Q15758, 541 residues long.
MolForge cross-references it against 0 known binders and
287 disease associations.
Target properties
| Protein name | Neutral amino acid transporter B(0) |
|---|
| UniProt accession | Q15758 |
|---|
| Gene | SLC1A5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 541 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (287)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- body height · score 0.27
- appendicular lean mass · score 0.25
- low density lipoprotein cholesterol measurement · score 0.23
- antisocial behaviour measurement · score 0.23
- attention deficit hyperactivity disorder · score 0.23
- substance abuse · score 0.23
- neuroinflammatory disorder · score 0.21
- hereditary spastic paraplegia · score 0.18
- eye measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15758-F1 | alphafold | PREDICTED | 78.31 | — |
Amino-acid sequence (541 residues)
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV M
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